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. 2021 Jul 20;12:4427. doi: 10.1038/s41467-021-24724-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Six-week-old male C57Bl/6 mice (15 per group) were infected with PR8 virus (WT) or recombinant virus having the K78R M2 mutant (K78R) (200 PFU) intranasally. Five mice per group were euthanized on days 3 and 6 post infection. Bronchoalveolar lavage fluids were collected to measure IAV titers. Lungs were harvested for histopathology. Survival of mice (five per group) was monitored until day 14. a Experimental plan. b Mouse body weight curves ± SD (n = 5 mice) up to day 14 post infection. c Mouse survival curves for 14 days (n = 5 mice). d Mean lung virus titer ± SD (n = 5 mice) on day 3 and 6 post infection. e Mouse lungs were isolated on day 3 and day 6 post infection. H&E staining was performed on lung sections. Scale bar represents 200 μm. Histological scoring is shown as mean ± SD (n = 4 mice). *P < 0.01; **P < 0.001; n.s., nonsignificant; unpaired two-tailed Student’s t-test, without any adjustments for multiple comparisons.