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. 2021 Jul 20;11:14789. doi: 10.1038/s41598-021-93034-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolic gene expression changes in LN GL are associated with changes in the EC, kidney cell, and fibroblast gene signatures. (a) Stepwise regression coefficients and (b–h) CART analysis for metabolic pathway signatures in all glomerular LN samples and CTLs. Values in the final CART leaves for each process represent the average GSVA score of samples that were assigned to that leaf. Each resulting CART decision tree was pruned once. For all calculations, the following sample numbers were used: LN GL [CTL (n = 14), Cl II (n = 8), Cl III/IV (n = 22)]. Significant p-values in (a) reflect significant coefficients in the stepwise regression model. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.