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. 2021 Jul 20;11:14814. doi: 10.1038/s41598-021-94064-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SCNAs in AA ESCC genomic regions encode cancer-related genes. (a) SCNA region profiles by 1 MB were visualized using CNApp. Dark blue represents homozygous deletion (copy number 0), white represents diploid (copy number 2), red represents copy number gains (the darkest red is copy number 8). (b) SCNA region frequency plot shows the percentage of samples with gains (red), losses (blue), and no alteration (gray) across chromosomes. Arrows represent the regions that also found in the 17 AA ESCC cohort analysis. (c) Plot shows the hierarchical clustering for samples correlation by Pearson correlation. Pearson r correlation coefficient r = 1 is yellow, r = − 1 dark navy color.