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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Arch Dis Child Fetal Neonatal Ed. 2021 Jan 21;106(5):467–473. doi: 10.1136/archdischild-2020-320664

Table 2:

In-hospital morbidities

n (column %)1 LOS n=786 LOCNC n=1601 Unaffected n=1553 p-value2
Infants with cranial imaging, N 781 1597 1547
 IVH any grade 295 (37.9) 525 (33.0) 447 (28.9) <0.001
 Severe IVH 167 (21.5) 262 (16.5) 225 (14.6) <0.001
 Severe IVH diagnosed within 7 days of birth 48 (6.2) 77 (4.8) 89 (5.8) 0.33
 Ventriculomegaly 200 (25.6) 334 (20.9) 242 (15.6) <0.001
  Cerebellar hemorrhage3 7/291 (2.4) 19/717 (2.6) 11/794 (1.4) 0.20
  Periventricular leukomalacia 39 (5.0) 96 (6.0) 54 (3.5) 0.004
  Porencephalic cyst 14 (1.8) 45 (2.8) 29 (1.9) 0.13
  Brain injury4 228 (29.3) 381 (23.9) 290 (18.8) <0.001
Survived in-hospital at 28 d, N 634 1490 1414
  Had ROP exam 609 1456 1390
   ROP 474 (77.8) 1100 (75.5) 883 (63.5) <0.001
   ROP stage 3 or worse 137 (22.5) 319 (21.9) 194 (14.0) <0.001
Survived to status5, N 598 1449 1412
  Had ROP assessed 586 1414 1343
   Severe ROP 6 76 (13.0) 187 (13.2) 87 (6.5) <0.001
Survived to 36 weeks PMA, N 602 1459 1414
  BPD 7 361 (60.2) 957 (66.0) 667 (47.5) <0.001

BPD, bronchopulmonary dysplasia. IVH, intraventricular hemorrhage. LOS, late-onset sepsis. LOCNC, late-onset blood culture-negative condition. PMA, post-menstrual age. PVL, periventricular leukomalacia. ROP, retinopathy of prematurity.

1

Information was missing for (n) infants: IVH (9); PVL (1); porencephalic cyst (1); brain injury (6); BPD, (21).

2

P-value by chi-square test.

3

Cerebellar hemorrhage was collected beginning April 2011.

4

Brain injury was defined as one or more of the following findings on cranial imaging: severe IVH, PVL, ventriculomegaly, porencephalic cyst, or cerebellar hemorrhage.

5

Includes infants discharged home or transferred before 120 days or still in the hospital at 120 days.

6

ROP determined was considered severe if either eye met one of the following criteria: had ROP surgery, anti-VEGF injection, or retinal detachment from ROP.

7

BPD was defined as oxygen use at 36 weeks PMA.