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. 2021 Jul 20;12(8):719. doi: 10.1038/s41419-021-03977-1

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Tumor sizes of T24-sh-NC and T24-sh-circUBE2K were shown in the figure. B Tumor growth of subcutaneous T24 tumors transfected with sh-NC (closed circles) or sh-circUBE2K (closed square) 21 days after tumor implantation. Average weights of tumors from sh-NC group and sh-circUBE2K group were shown in the histogram. Error bars indicate SD. C Expression levels of ARHGAP5, Vimentin, N-Cadherin, and Ki-67 were measured by immunohistochemical staining. Representative views of slides from sh-NC group (Left panel) and sh-circUBE2K (Right panel) were shown. D Bioluminescence imaging in mice metastasis model (Left, NC-T24) and circUBE2K knockdown T24 cells (Right, si-circUBE2K-T24). Imaging revealed that silencing circUBE2K reduced metastasis potential of T24 cells. E Representative hematoxylin and eosin-stained sections of lung tissues from NC-T24 (Top) and si-circUBE2K-T24 (Bottom) bearing mice. F System role of circUBE2K in the oncogenesis scheme of bladder cancer.