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. 2021 Jul 20;11:399. doi: 10.1038/s41398-021-01490-9

Fig. 1. 1q21.1, 16p11.2, 22q11.2, and 15q11.2 exert rich effects on global brain measures.

Fig. 1

Total intracranial volume (a), total surface area (b), total grey matter volume (c) and mean cortical thickness (d) for clinically and non-clinically ascertained CNVs. Z scores for clinically and non-clinically ascertained CNVs were calculated using 331 and 965 controls, respectively, adjusting for age, age2, sex and site as a random factor. Y axis values are z scores. X axis are CNV groups. Significant difference between CNV group and corresponding control group is indicated with a star. Horizontal bars with stars show significant differences between deletions and duplications within the same locus. TIV total intracranial volume, SA surface area, GM grey matter, CT cortical thickness.