Table 3.

Unadjusted and adjusted odds ratios for small vessel disease markers on CT and MRI in patients with intracerebral haemorrhage and prior anticoagulation therapy (vs no prior anticoagulation therapy)

			Unadjusted OR	P value	Adjusted* OR	P value
Leukoaraiosis/white matter lesions
CT	Anterior region		1.2 (1.0–1.4)	0.023	0.8 (0.6–1.1)	0.209
	Posterior region		1.2 (1.0–1.3)	0.038	0.8 (0.6–1.1)	0.234
MRI	Periventricular white matter		1.7 (1.2–2.4)	0.003	1.2 (0.6–2.3)	0.656
	Deep white matter		1.6 (1.2–2.1)	0.001	1.3 (0.8–2.2)	0.264
Lacunes
CT	Any lacunes		0.8 (0.5–1.2)	0.274	1.0 (0.5–2.2)	0.948
MRI	Any lacunes		1.5 (0.5–4.7)	0.451	0.6 (0.1–7.8)	0.666
Atrophy
CT	Cortical atrophy		2.0 (1.6–2.5)	<0.001	0.9 (0.6–1.4)	0.671
	Deep atrophy		1.6 (1.3–1.9)	<0.001	1.0 (0.7–1.5)	0.837
MRI	Global cortical atrophy		1.7 (1.2–2.3)	0.004	0.6 (0.3–1.4)	0.267
	Medial temporal lobe		1.2 (0.9–1.7)	0.200	0.7 (0.4–1.2)	0.187
Cerebral microbleeds, cortical superficial siderosis and perivascular spaces
MRI	Perivascular spaces	Centrum semiovale	0.9 (0.7–1.2)	0.567	1.2 (0.7–2.0)	0.589
		Basal ganglia	2.0 (1.2–3.2)	0.006	1.5 (0.6–3.6)	0.393
	Any cortical superficial siderosis		1.3 (0.4–4.2)	0.710	1.1 (0.1–1.7)	0.118
	Any cerebral microbleeds		1.6 (0.9–2.8)	0.098	1.8 (0.6–5.0)	0.279

*All CT analysis were adjusted for age, history of ischaemic stroke, history of ICH, atrial fibrillation, myocardial infarction, diabetes mellitus, hypertension, hypercholesterolaemia, current smoking and concomitant medication with antiplatelet agents, antihypertensive agents and statins.

*All MRI analysis were adjusted for age, hypertension, diabetes mellitus, atrial fibrillation, hypercholesterolaemia, current smoking and antihypertensive treatment.