Table 3.

Summary of the independent association results from the stratified analysis

Gene	Alleles	OR*	P value*	Conditioned P value	Phenotype	OR†	Intracase P value†
HLA-DQA1	DQA1*02:01	0.54	5.23E-51	NA‡	lcSSc	0.71	2.08E-08
HLA-DQA1	DQA1*05:01	1.49	1.16E-30	1.59E-11	dcSSc	1.30	1.76E-11
HLA-DRB1	DRB1*08:01	3.18	9.73E-57	4.00E-64	ACA	2.17	1.42E-10
HLA-DRB1	DRB1*07:01	0.36	1.17E-63	1.84E-45	ACA	0.42	3.85E-27
HLA-DPA1	DPA1*02:01	1.87	7.91E-43	2.93E-19	ATA	2.41	1.09E-40
HLA-DQB1	DQB1*03:01	1.86	7.11E-47	7.00E-19	ATA	1.67	1.73E-22

*Association effect and p value compared with the control group.

†Association effect and p value in the intracase comparisons (dcSSc with lcSSc and ATA with ACA).

‡Not available as it was the most significant allele in the sequential conditional model.

ACA, anticentromere; ATA, antitopoisomerase; dcSSc, diffuse cutaneous systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis.