Table 2B.
Amygdala volume and MMSE over 5 years.
| Model 3c | Model 4c | |||||||
|---|---|---|---|---|---|---|---|---|
| FE | 95% CI | p-value | q-value | FE | 95% CI | p-value | q-value | |
| Time (T) | −3.01 | −3.41, −2.59 | <0.001 | −2.64 | −3.08, −2.20 | <0.001 | ||
| Centerb | ||||||||
| 1 | 0.25 | −2.40, 2.90 | 0.852 | 1.20 | −1.49, 3.91 | 0.381 | ||
| 2 | −0.32 | −2.77, 2.13 | 0.797 | 0.16 | −2.22, 2.55 | 0.894 | ||
| Age | −0.16 | −0.23, −0.09 | <0.001 | |||||
| Age × T | 0.07 | 0.01, 0.14 | 0.025 | |||||
| Gender (female) | 0.66 | −0.69, −2.01 | 0.336 | |||||
| Diagnosis (DLB) | 0.74 | −0.65, 2.13 | 0.295 | |||||
| Diagnosis (DLB) × T | −1.07 | −1.99, −1.16 | 0.022* | |||||
| Amygdala (% ICV) | 0.06 | −0.95, 1.07 | 0.906 | NA | 0.16 | −0.81, 1.12 | 0.747 | NA |
| Amygdala (% ICV) × T | 0.70 | 0.24, 1.16 | 0.003 | 0.020 | 0.66 | 0.29, 1.03 | 0.001 | 0.010 |
DLB, Dementia with Lewy bodies; FE, Fixed effect; CI, Confidence interval; MMSE, Mini-mental State Examination; NPI, Neuropsychiatric inventory; ICV, Total intracranial volume; T, Time.
Generalized mixed-effects model with the absolute NPI total score (added a constant of one to provide strictly positive distribution) at each time point of the study as the dependent variable, and intracranial volume-normalized amygdala as independent variable, based on gamma distribution and log-link with random intercepts and slopes in an unstructured variance–covariance matrix with covariates as listed. In a model with time and center as predictors (not in Table), Amygdala (% ICV) had an FE of −0.14 [−0.25, −0.02], p = 0.014, q = 0.041.
Twenty-three participants from reference center (Bergen), 11 in center coded as 1 (Haugesund), 55 in center coded as 2 (Stavanger).
Linear mixed-effects model with the absolute MMSE score at each time point of the study as the outcome variable, intracranial volume-normalized amygdala as independent variable, random intercepts, and slopes in an unstructured variance–covariance matrix and covariates as listed.
Time interactions with intracranial volume-normalized amygdala were also evaluated in the NPI total score and the MMSE models based on the Akaike Information Criterion (AIC) and the Bayesian Information Criterion (BIC). Any significant interaction was included in the above models.
p-values and q < 0.05 are printed in bold. Multiple testing corrected p-values (q-values) are listed only for Amygdala (% ICV) (Models 1 and 2), or its interaction with time (Models 3 and 4).