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. Author manuscript; available in PMC: 2021 Jul 21.

Published in final edited form as: J Control Release. 2015 Feb 11;204:20–29. doi: 10.1016/j.jconrel.2015.01.036

Table 2.

Enhancement of polymer-mediated EGFP Expression by PLK1 inhibitors identified as leads from the screen.

PC3-PSMA Cells
	1,4C-1,4bis		PEI
PLK1 Inhibitor	EGFP+	Fluor/Cell	EGFP+	Fluor/Cell
BI 2536 (25 nM)	5.1 ± 1.0^*	15.8 ± 4.2^*	3.6 ± 1.6^*	3.4 ± 1.1^*
BI 6727 (100 nM)	4.9 ± 4.0	45.8 ± 45.2
HMN-214 (3.3 μM)	4.3 ± 0.5^*	5.6 ± 0.7^*	6.7 ± 4.0^*	15.5 ± 12.8
ON01910 (100 nM)	6.3 ± 3.3	32.3 ± 17.0
MB49 Cells
	1,4C-1,4bis		PEI
PLK1 Inhibitor	EGFP+	Fluor/Cell	EGFP+	Fluor/Cell
BI 2536 (100 nm)	2.5 ± 0.3^*	9.7 ± 3.2^*	0.5 ± 0.2	0.4 ± 1.7
HMN-214 (3.3 μM)	1.8 ± 0.4^*	9.8 ± 2.3^*

^*

p<0.05, Student’s t test (two tailed)