Table 3.

Normal Tissue Complication Probability (NTCP) values for grade 2+ radiation pneumonitis are shown here for the average functional lung volume metrics for the standard and functional plans with both the VMAT and IMPT methods

Grade 2+ Toxicity
Dose metric for NTCP	Toxicity probability of the mean (range)—VMAT standard	Toxicity probability of the mean (range)—VMAT functional	Absolute reduction (range)
fV20 Gy	31.3% (5.9%–67.8%)	25.1% (5.5%–60.2%)	6.2% (−0.1%–13.1%)
fV30 Gy	24.5% (9%–50.1%)	21.5% (8.5%–45.8%)	3% (0.1%–7.4%)
fVMLD	24.1% (11.9%–33.4%)	21.8% (11.4%–31.5%)	2.3% (−0.1%–5.5%)
Dose metric for NTCP	Toxicity probability of the mean (range)—IMPT Standard	Toxicity probability of the mean (range)—IMPT Functional	Absolute Reduction (Range)
fV20 Gy	17.6% (4.4%–51.3%)	12.7% (3.9%–36.1%)	5.70% (0%–26%)
fV30 Gy	19% (7.9%–47.5%)	15.7% (7.3%–35.9%)	3.30% (0%–15.3%)
fVMLD	14.6% (7.7%–25.4%)	12.9% (7.4%–21.3%)	1.80% (0%–5.9%)