Table A1.

Normal Tissue Complication Probability values for grade 3+ radiation pneumonitis are shown here for the functional lung volume metrics for the standard and functional plans in both the proton and photon modalities

Grade 3+ toxicity
Dose metric for NTCP	Toxicity probability of the mean—VMAT standard	Toxicity probability of the mean—VMAT functional	Absolute reduction [range of reduction]
fV20 Gy	15.5% (2.9%–40.4%)	12.1% (2.7%–34.2%)	3.4% (−0.1%–8.1%)
fV30 Gy	11.3% (3.6%–27.8%)	9.7% (3.4%–24.7%)	1.6% (0%–4.4%)
fVMLD	11.1% (4.9%–16.4%)	9.8% (4.7%–15.3%)	1.3% (0%–3%)
Dose metric for NTCP	Toxicity probability of the mean—IMPT standard	Toxicity probability of the mean—IMPT functional	Absolute reduction [range of reduction]
fV20 Gy	8.4% (2.2%–27.7%)	6% (2%–18.1%)	2.4% (0%–15.4%)
fV30 Gy	8.4% (3.1%–25.9%)	6.7% (2.9%–18%)	1.7% (0%–10.2%)
fVMLD	6.2% (3.1%–11.8%)	5.4% (2.9%–9.6%)	0.8% (0%–3.2%)