Table B1.

DVH dose metrics comparisons between non‐dose‐escalated and dose‐escalated IMPT plans (n = 22)

	Intensity modulated proton—standard			Intensity modulated proton—functional
	Nondose‐escalated plan	Dose‐escalated Plan	P value	Nondose‐escalated Plan	Dose‐escalated Plan	P value
CTV metrics
CTV max (RBE[Gy])	63.82	74.36	<0.00	64.64	74.36	<0.00
OAR Metrics
Total MLD (RBE[Gy])	10.71	10.97	0.37	9.72	9.97	0.43
Total lung V20 (%)	21.26	20.99	0.84	18.60	18.02	0.39
Total lung V5 (%)	30.77	30.24	0.48	28.77	28.76	0.99
Esophagus mean (RBE[Gy])	19.04	20.34	0.33	18.97	20.51	0.23
Heart mean (RBE[Gy])	5.38	4.78	0.12	5.06	4.86	0.38
Cord max (RBE[Gy])	32.56	35.06	0.23	34.38	35.93	0.37
Functional lung metrics
Ipsilateral
MLD (RBE[Gy])	21.210	21.213	0.7	17.90	17.81	0.88
Lung V5 (%)	60.86	58.44	0.004	55.19	53.74	0.17
Lung V20 (%)	42.78	41.45	0.51	34.08	31.52	0.053
Lung V30 (%)	33.17	32.86	0.94	26.79	24.71	0.08
Contralateral
MLD (RBE[Gy])	1.91	1.85	0.85	1.90	1.21	0.11
Lung V5 (%)	8.47	7.93	0.39	7.04	6.80	0.7
Lung V20 (%)	3.02	2.69	0.4	1.82	1.26	0.11
Lung V30 (%)	1.26	1.05	0.4	0.92	0.64	0.17
Total lung
MLD (RBE[Gy])	10.17	10.18	0.68	8.52	8.38	0.52
Lung V5 (%)	31.10	29.96	0.03	27.82	27.13	0.22
Lung V10 (%)	27.11	25.89	0.02	22.55	21.81	0.18
Lung V20 (%)	20.26	19.65	0.52	15.80	14.43	0.017
Lung V30 (%)	15.09	14.80	0.84	12.15	11.12	0.02
Lung V40 (%)	11.33	11.02	0.58	9.43	8.83	0.08
Lung V50 (%)	7.61	7.73	0.52	6.46	6.48	0.95