Table 2.
Summary statistics of clinical and demographic variables among MCI groups at study entry (baseline).
| Cognitively intact | MCI- inhibition | MCI-working memory | MCI-motor planning | MCI-information integration | MCI-sensory processing | MCI- learning—memory | |
|---|---|---|---|---|---|---|---|
| N (% of total prodromal HD sample) | 357 (47%) | 130 (17%) | 94 (12%) | 195 (25%) | 240 (31%) | 145 (19%) | 214 (28%) |
| Continuous variables | |||||||
| Age | |||||||
| Mean | 40.3 | 38.7 | 41.3 | 40.8 | 38.6* | 42.5* | 40.3 |
| SD | 9.4 | 9.9 | 10.0 | 9.8 | 10.4 | 11.1 | 10.0 |
| Range | [21.8, 72.9] | [20.3, 65.7] | [26.0, 65.6] | [18.1, 75.9] | [20.0, 67.9] | [18.1, 75.9] | [23.2, 75.0] |
| CAP | |||||||
| Mean | 316.4 | 379.9*** | 392.6** | 390.9** | 386.0** | 391.0** | 382.1*** |
| SD | 70.7 | 98.7 | 82.7 | 87.4 | 92.8 | 88.1 | 90.4 |
| Range | [145.7, 505.5] | [168.1, 845.8] | [186.2, 652.0] | [168.1, 845.8] | [111.1, 845.8] | [119.0, 652.0] | [160.3, 845.8] |
| TMS | |||||||
| Mean | 3.3 | 10.1** | 8.6** | 7.6** | 8.8** | 7.9** | 8.0*** |
| SD | 3.5 | 9.7 | 9.1 | 6.4 | 8.7 | 9.2 | 7.9 |
| Range | [0, 18] | [0, 47] | [0, 44] | [0, 34] | [0, 47] | [0, 47] | [0, 44] |
| Categorical variable n (%) | |||||||
| Sex | |||||||
| Female | 232 (65.0) | 80 (61.5) | 57 (60.5) | 152 (78.5)** | 139 (57.9)** | 66 (45.5)** | 100 (44.6)** |
| Male | 125 (35.0) | 50 (38.5) | 37 (39.5) | 43 (21.5) | 101 (42.1) | 79 (54.5) | 113 (55.4) |
| Race | |||||||
| White | 347 (97.2) | 126 (96.9) | 94 (100) | 192 (98.5) | 236 (98.3) | 139 (95.9) | 207 (96.7) |
| Others | 10 (2.8) | 4 (3.1) | 0 (0) | 3 (1.5) | 4 (1.7) | 6 (4.1) | 7 (3.3) |
MCI, Mild Cognitive Impairment; CAP, CAG by Age Product; TMS, Total Motor Score from the Unified HD Rating Scale.
***
p < 0.001;
**
0.001 ≤
p < 0.01;
*
0.01 ≤
p < 0.05.