Table 3.
Summary of average percentage brain atrophy (and its 95% confidence interval) in the six selected brain regions for prodromal HD individuals with and without MCI.
| MRI volumes | Control group mean | Cognitively intact | MCI inhibition | MCI working memory | MCI motor planning | MCI information integration | MCI sensory processing | MCI learning memory |
|---|---|---|---|---|---|---|---|---|
| Caudate | 6590.5 | −9.9 (−12.3, −7.6) | −20.6 (−24.7, −16.5) | −24.5 (−28.8, −20.3) | −25.4 (−28.3, −22.4) | −22.5 (−25.4, −19.6) | −21.2 (−24.9, −17.5) | −18.5 (−21.6, −15.5) |
| Putamen | 8554.2 | −11.2 (−13.4, −8.9) | −21.7 (−25.8, −17.6) | −24.5 (−28.5, −20.5) | −27.1 (−30.0, −24.2) | −23.2 (−26.1, −20.3) | −22.9 (−26.6, −19.2) | −18.6 (−21.7, −15.5) |
| Globus Pallidum | 2765.3 | −12.8 (−15.0, −10.5) | −22.2 (−26.6, −17.7) | −26.5 (−30.7, −22.2) | −29.0 (−32.0, −26.0) | −23.9 (−26.9, −20.9) | −23.2 (−27.0, −19.2) | −18.8 (−22.1, −15.5) |
| Cerebral Gray Matter | 112116.6 | 0.3 (−1.4, 2.1) | −0.4 (−2.8, 2.0) | 0.3 (−2.0, 2.7) | −1.1 (−3.0, 1.0) | 0.6 (−1.4, 2.6) | 2.6 (0.2, 5.0) | 1.8 (−0.2, 3.9) |
| Cerebral White Matter | 26074.3 | −3.8 (−6.0, −1.5) | −4.5 (−7.6, −1.3) | −5.5 (−9.2, −1.4) | −8.4 (−10.7, −6.0) | −4.5 (−7.1, −1.8) | −2.8 (−5.9, 0.4) | −3.1 (−5.8, −0.4) |
MRI, Magnetic Resonance Imaging; MCI, Mild Cognitive Impairment.
Values are mean differences in percentage relative to the control group (negative indicates less than control mean).