Table 2. Differentially expressed pathways based on GSVA analysis of parent genes from survival-related AS events from C2 curated gene sets in MSigDB database between high- and low-risk groups patients (Adj. P <0.05).
| Pathway | LogFC | AveExpr | t | P.Value | Adj.P.Val | B |
|---|---|---|---|---|---|---|
| REACTOME_COSTIMULATION _BY_THE_CD28_ FAMILY |
-0.2840 | -0.0205 | -4.8911 | 2.51E-06 | 0.0036 | 4.4716 |
| PARK_HSC_AND_ MULTIPOTENT_ PROGENITORS |
-0.1900 | -0.0063 | -4.3184 | 2.81E-05 | 0.0136 | 2.2952 |
| PECE_MAMMARY_ STEM_CELL_DN |
0.2058 | 0.0063 | 4.1734 | 5.01E-05 | 0.0162 | 1.7769 |
| REACTOME_METABOLISM _OF_VITAMINS_AND_ COFACTORS |
-0.1409 | -0.0020 | -4.1459 | 5.58E-05 | 0.0162 | 1.6802 |
| KUMAR_TARGETS _OF_MLL_AF9_ FUSION |
-0.1118 | 0.0076 | -4.0506 | 8.09E-05 | 0.0168 | 1.3488 |
| ELVIDGE_ HYPOXIA_DN |
-0.1538 | -0.0008 | -3.9581 | 0.0001 | 0.0208 | 1.0331 |
| RADMACHER_AML _PROGNOSIS |
-0.1746 | -0.0032 | -3.9290 | 0.0001 | 0.0208 | 0.9350 |
| REACTOME_FLT3 _SIGNALING |
-0.1127 | -0.0058 | -3.5445 | 0.0005 | 0.0302 | -0.3057 |
| SANSOM_APC _TARGETS_DN |
-0.1736 | -0.0105 | -3.4294 | 0.0008 | 0.0365 | -0.6564 |
| REACTOME_MAPK6 _MAPK4_SIGNALING |
-0.1840 | -0.0218 | -3.2583 | 0.0014 | 0.0494 | -1.1593 |