Table 3.

Reporting adverse events, COI and funding before and after consort 2001 by included studies (N=237 and 195, respectively)

Reporting		Studies up to 2001 (inclusive) (n=237)		Studies from 2002 (inclusive) (n=195)		Significance of difference
							N	%	N	%
		Adverse events reporting	Drug-related adverse events reported (other than death/antibiotic resistance)
Yes	146		62	121	62
No*	91		38	74	38	p=0.92
Deaths reported
Yes	45		19	42	22
No*	192		81	153	78	p=0.51
Antibiotic resistance reported
Yes	93		39	65	33
No	144		61	130	67	p=0.21
COI	COI statement provided?
	Yes	5	2	107	55
	No	232	98	88	45	p<0.001
	COI present?
	Present	1	0	27	14
	Absent	4	2	80	41
	Unclear (no COI statement provided)	232	98	88	45	p<0.001
Funding	Funding statement provided?
	Yes	146	62	136	70
	No	91	38	59	30	p=0.077

*Trials whose reporting of adverse events was unclear were included in the ‘not reported’ category

COI, conflict of interest.