Table 4.

Sensitivity analyses based on those on a single sedation strategy or those whose sedation strategy was dominant for ≥6 hours over the other two strategies

Outcome	Dominant sedation strategy	Propensity score-matched OR, mean ratio or rate ratio (95% CI)*
Delirium ever	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.29 (0.99 to 1.69)
	Midazolam (n=231)	1.64 (1.12 to 2.41)
Delirium or ICU death	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.38 (1.05 to 1.81)
	Midazolam (n=231)	1.75 (1.18 to 2.60)
ICU mortality	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.82 (1.18 to 2.84)
	Midazolam (n=231)	1.31 (0.73 to 2.39)
Hospital mortality	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.69 (1.19 to 2.42)
	Midazolam (n=231)	1.50 (0.92 to 2.49)
Died within 30 days of ICU admission	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.84 (1.27 to 2.68)
	Midazolam (n=231)	1.14 (0.69 to 1.89)
Died within 1 year of ICU admission	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.38 (1.02 to 1.86)
	Midazolam (n=231)	1.16 (0.77 to 1.76)
Died within 1.5 years of ICU admission	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.25 (0.94 to 1.66)
	Midazolam (n=231)	1.25 (0.84 to 1.85)
ICU length of stay, mean ratio (95% CI)	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.23 (1.09 to 1.39)
	Midazolam (n=231)	1.01 (0.86 to 1.20)
Hospital length of stay, mean ratio (95% CI)	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.31 (1.13 to 1.51)
	Midazolam (n=231)	1.01 (0.83 to 1.22)
Duration of invasive ventilation, mean ratio (95% CI)	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.35 (1.14 to 1.59)
	Midazolam (n=231)	1.17 (0.94 to 1.46)
No of delirium days, rate ratio (95% CI)	Propofol	1.00 (reference group)
	Fentanyl (n=476)	1.19 (0.99 to 1.43)
	Midazolam (n=231)	1.11 (0.85 to 1.44)

Bold values demonstrate a statistically signficant result.

*Data presented as ORs unless otherwise indicated.

ICU, intensive care unit.