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. 2021 Jul 7;12:673501. doi: 10.3389/fgene.2021.673501

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Copyright © 2021 Zuo, Li, Zheng, Sun, Yang and Xin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of the final ceRNA hub regulatory network. (A) Construction of the ceRNA hub regulatory network based on the mRNAs associated with LUAD prognosis. As shown in (B–D), expression of hsa_circ_0004789, hsa_circ_0043256, and hsa_circ_0049271 in 39 LUAD tissues and corresponding non-tumor tissues were detected by qRT-PCR, respectively (p = 0.0027, p < 0.001, and p = 0.6936). (E) After qRT-PCR verification, the final ceRNA hub regulatory network was constructed. In the ceRNA hub regulatory network, red diamonds indicate circRNAs, green triangles indicate miRNAs, and blue ovals indicate mRNAs.