The relationships between serine hydroxymethyl transferase 1 (SHMT1) methylation and homocysteine (Hcy), high-density lipoprotein (HDL), BMI, and low-density lipoprotein (LDL) in different groups. (A, B) SHMT1 methylation was associated with Hcy in stroke cases (stroke cases, p= 0.034, controls, p = 0.950; total, p = 0.011, (A) and HDL in controls (stroke cases, p = 0.146, controls, p < 0.0001, total, p = 0.001, (B) using regression analysis. (C, D) BMI (stroke cases, p= 0.821, controls, p = 0.937; total, p = 0.673, (C) and LDL (stroke cases, p = 0.603, controls, p = 0.646; total, p = 0.221, (D) showed no association with SHMT1 methylation though regression analysis.