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. 2021 Jul 7;12:648815. doi: 10.3389/fimmu.2021.648815

Figure 2.

Figure 2

Miz1 binds to the Ace2 promoter in a POZ-domain dependent manner and TNF reduces Miz1 binding in mouse lung epithelial cells as analyzed by ChIP-seq. (A) ChIP-seq traces of wild type or mutant Miz1 proteins (δPOZ or S178A) on the Ace2 promoter. Input is shown as control. (B) ChIP-seq traces of RNA Pol II on the Ace2 promoter in MLE-12/Miz1(WT) and MLE-12/Miz1(δPOZ) cells. Input is shown as control. (C) ChIP-seq traces of Miz1 on the Ace2 promoter in TNF-non-treated or -treated MLE-12/Miz1(WT) cells. Input is shown as control. (D) ChIP-seq traces of RNA Pol II on the Ace2 promoter in TNF-non-treated or -treated MLE-12/Miz1(WT)cells. Input is shown as control.