Figure 3.
The pharmacological inhibition on Kdm6a decreases food intake of DIO mice but not lean mice. A) The mice received vehicle or GSK‐J4 (30 mg kg−1) for 10 d. The food intake was recorded. *p < 0.05, GSK‐J4 vs Vehicle; #p < 0.05, ##p < 0.01, light vs dark phage (n = 5 in each group of HFD mice; n = 3 in each group of ND mice for (A)–(E)). B) The locomotor activities of mice. #p < 0.05, light vs dark phage. C) Oxygen consumption (VO2) monitored over a 24 h period, shown as averaged values. #p < 0.05, light vs dark phage. D) Carbon dioxide production (VCO2) monitored over a 24 h period, shown as averaged values. #p < 0.05, light vs dark phage. E) The respiratory exchange rate (RER) was analyzed for 24 h. #p < 0.05, light vs dark phage.