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. 2021 May 13;8(14):2004319. doi: 10.1002/advs.202004319

Figure 6.

Figure 6

The specific Kdm6a knockout in the hypothalamus is responsible to leptin‐reduced the body weight and food intake. A) The mice received AAV of GFP or Cre microinjection in the hypothalamus (n = 6 in each group for (A)–(D)). B) Oxygen consumption (VO2) monitored over a 24 h period, shown as averaged values. #p < 0.05, light vs dark phage. C) Carbon dioxide production (VCO2) monitored over a 24 h period, shown as averaged values. #p < 0.05, light vs dark phage. D) The respiratory exchange rate (RER) was analyzed for 24 h. #p < 0.05, light vs dark phage. E) The mice received microinjection with AAV of GFP, Cre, Cry1, or Cre plus Cry1 in the hypothalamus (n = 6 in each group for (E)–(H)). Daily food intake before the leptin treatment was recorded. F) Body weight before the leptin treatment. G) Daily food intake after the mice received the leptin treatment. H) Body weight after the mice received the leptin treatment.