Table 3.
Top enriched functions for downregulated and upregulated proteins in OTUD7A‐depleted A673 cells
| Function | Count | p‐value | Fold enrichment |
|---|---|---|---|
| Disulfide bond | 114 | 3.01 × 10−25 | 2.77 |
| Transcription factor activity, sequence‐specific DNA binding | 62 | 1.93 × 10−10 | 2.36 |
| Homeobox | 21 | 7.90 × 10−10 | 5.09 |
| Immunoglobulin‐like fold | 35 | 1.51 × 10−9 | 3.17 |
| Extracellular matrix organization | 25 | 1.83 × 10−9 | 4.13 |
| Epidermal‐growth‐factor‐like domain | 17 | 4.44 × 10−7 | 4.43 |
| Protein digestion and absorption | 11 | 1.32 × 10−6 | 6.72 |
| Insulin‐like growth factor binding protein, N‐terminal | 13 | 3.04 × 10−6 | 5.08 |
| High mobility group (HMG) box domain | 13 | 8.98 × 10−6 | 4.65 |
| Integrin complex | 6 | 3.10 × 10−4 | 8.31 |
| Antiviral defense | 29 | 8.83 × 10−23 | 11.31 |
| Type I interferon signaling pathway | 21 | 5.96 × 10−20 | 15.66 |
| Innate immunity | 25 | 1.68 × 10−13 | 6.6 |
| Response to virus | 16 | 3.93 × 10−9 | 7.01 |
| 2ʹ‐5ʹ‐Oligoadenylate synthetase activity | 4 | 1.69 × 10−4 | 28.2 |
| retinoic acid‐inducible gene I (RIG‐I)‐like receptor signaling pathway | 8 | 9.57 × 10−4 | 4.88 |
| Thiol protease | 11 | 0.001573 | 3.33 |
| Response to cytokine | 8 | 0.003901 | 3.92 |
| Mitophagy | 6 | 0.004002 | 5.52 |
| Nucleophagy | 16 | 0.007451 | 2.14 |