Table 3.
Identified proteins with significant differences in computed relative abundances between male wildtype and male knockout animals (MWT vs MKO).
| Name | NSAF p-value | emPAI p-value | KO/WT ratio NSAF | emPAI |
|---|---|---|---|
| Kallikrein 1-related peptidase b22 | <0.0001 | <0.0001 | 71 | 29 |
| Carbonic anhydrase 6 | 0.00016 | 0.016 | 3.4 | 1.5 |
| Neprilysin | 0.00022 | 0.0026 | 0.07 | 0.07 |
| Kallikrein 1-related peptidase b27 | 0.00076 | 0.018 | 0.3 | 0.7 |
| Myosin-11 | 0.00093 | 0.0039 | 1.5 | 1.2 |
| ABPBG27 | 0.0012 | 0.019 | 3.8 | 2.7 |
| Mannose-P-dolichol utilization defect 1 | 0.0016 | 0.0011 | 5.2 | 4.9 |
| Beta-globin | 0.0021 | <0.0001 | INF | 24 |
| Carbonic anhydrase 2 | 0.0033 | 0.0013 | 0.2 | 0.2 |
| Alpha-2-HS-glycoprotein | 0.0035 | 0.0071 | 2 | 1.7 |
| Beta-hexosaminidase subunit beta | 0.0041 | 0.0015 | 0.3 | 0.3 |
| m7GpppX diphosphatase | 0.009 | 0.044 | 3 | 2.3 |
| Lumican | 0.009 | 0.0051 | 0.6 | 0.5 |
| Ragulator complex protein LAMTOR1 | 0.011 | 0.011 | 0.2 | 0.2 |
| Dihydrolipoyl transacetylase | 0.012 | 0.021 | 2.8 | 2.5 |
| 60S ribosomal protein L30 | 0.013 | 0.044 | 7.3 | 5.4 |
| Cysteine-rich secretory protein 1 | 0.013 | 0.013 | 0 | 0 |
| Carboxypeptidase Q, Isof. 2 | 0.013 | 0.031 | 0.2 | 0.3 |
| LRBA | 0.015 | 0.014 | 0.2 | 0.2 |
| Pro-epidermal growth factor | 0.016 | 0.0086 | 0.6 | 0.6 |
| TRX-dependent peroxide reductase | 0.018 | 0.025 | 5.4 | 5.1 |
| Kallikrein 1-related peptidase b24 | 0.018 | 0.0073 | 0.6 | 0.7 |
| Tubulin alpha-1C chain | 0.019 | 0.017 | 1.4 | 1.4 |
| 40S ribosomal protein SA | 0.02 | 0.039 | 2.4 | 2.1 |
| DnaJ homolog subfamily C member 3 | 0.022 | 0.011 | 0.3 | 0.2 |
| Aldose reductase | 0.023 | 0.033 | 4.7 | 4.6 |
| Protein Sec24b | 0.023 | 0.033 | INF | INF |
| Alpha-1-antitrypsin 1-5 | 0.041 | 0.049 | 7.2 | 4.8 |
| Polypyrimidine tract-binding protein 1 | 0.042 | 0.03 | 2.4 | 2.3 |
| Aconitate hydratase, mitochondrial | 0.00094 | 0.12 | 1.4 | 1.1 |
| ATP synthase subunit beta | 0.0025 | 0.24 | 1.3 | 1.2 |
| Hemoglobin subunit beta-1 | 0.003 | 0.89 | 1.7 | 1 |
| Solute carrier family 12 member 2 | 0.0045 | 0.05 | 2.3 | 1.8 |
| Kallikrein 1-related peptidase-like b4 | 0.0048 | 0.26 | 0.6 | 0.8 |
| Kallikrein 1-related peptidase b8 | 0.0077 | 0.46 | 0.7 | 0.8 |
| Kallikrein 1-related peptidase b1 | 0.011 | 0.47 | 0.6 | 0.9 |
| PPP1CA | 0.022 | 0.12 | 2.6 | 1.9 |
| Beta-nerve growth factor | 0.022 | 0.28 | 0.3 | 0.7 |
| Isochorismatase domain containing 2a | 0.025 | 0.09 | 3.6 | 2.6 |
| Phospholipase C beta 4 | 0.025 | 0.085 | 1.9 | 1.5 |
| Annexin A11 | 0.026 | 0.058 | 2.5 | 2.2 |
| Protein ERGIC-53 | 0.028 | 0.073 | 5.1 | 4.4 |
| 14-3-3 protein gamma | 0.039 | 0.22 | 1.8 | 1.3 |
| Ribosomal protein L15 | 0.039 | 0.082 | 3.2 | 2.8 |
| Plastin-2 | 0.041 | 0.12 | 2.5 | 2 |
| Signal peptidase complex subunit 2 | 0.045 | 0.092 | 3.3 | 3.2 |
| Cytochrome b-c1 complex subunit 2 | 0.047 | 0.095 | 1.8 | 1.6 |
| Mesencephalic astrocyte-derived NF | 0.048 | 0.1 | 1.8 | 1.7 |
| Serine protease inhibitor A3K | 0.072 | 0.036 | 0.5 | 0.4 |
| Creatine kinase U-type, mitochondrial | 0.078 | 0.024 | 0.7 | 0.5 |
| Protein transport protein Sec31A, Isof.2 | 0.094 | 0.035 | 0.5 | 0.4 |
| Heat shock cognate 71 kDa protein | 0.18 | 0.0023 | 0.8 | 0.6 |
| Cysteine and glycine-rich protein 1 | 0.48 | 0.023 | 0.8 | 0.6 |
| Cytoplasmic dynein 1 interm. chain 2 | 0.57 | 0.033 | 0.9 | 0.6 |
| Hemoglobin subunit beta-2 | 0.9 | 0.0019 | 1 | 0.2 |
p values < 0.05 were considered significant. INF, infinite ratio (denominator = 0).