FIGURE 1.

RNA methylation in T cell homeostasis. For naive T cell, SOCS family genes with m6A modification exhibit slower mRNA decay and increased protein expression levels. The increased SOCS family activity inhibits the IL-7/STAT5 signaling pathway and activates the TCR/ERK/AKT pathway, which lead to decreased T cell proliferation and differentiation. For Treg cell, reduction in m6A enhances the mRNA stability of SOCS genes and the proteins levels. The increased SOCS family activity blocks signal transduction of the IL2-STAT5 pathway, which lead to Treg cell suppression function lost. These two evidences shows that m6A modification plays an important role in maintaining T cell homeostasis.