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. 2021 May 19;12(7):1239–1243. doi: 10.1039/d1md00067e

Scheme 1. Synthesis of building block 7. Reagents and conditions: a) Ph2SO, Tf2O, TTBP, DCM, preactivation of compound 2 at −72 °C for 15 min, then addition of compound 3, 85%; b) NaOMe, DCM/MeOH, 82%; c) 1,3-propanedithiol, Et3N, DCM/MeOH, 86%; d) TrocCl, NaHCO3, THF, 64%.

Scheme 1