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. 2021 Jul 7;9:707970. doi: 10.3389/fcell.2021.707970

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Copyright © 2021 Dong, Liu, Deng, Shao, Tian, Chen, Huang, Lin, Chen and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RAC1 expression is positively regulated by C1GALT1 in LUAD. (A) Heat maps showing the top 50 genes positively correlated with C1GALT1 in TCGA-LUAD samples. (B) Correlation between RAC1 and C1GALT1 in TCGA-LUAD samples. (C) GSEA analysis of C1GALT1-associated genes in TCGA-LUAD samples. (D) RAC1 expression in paired (left) or unpaired (right) LUAD tissues and normal lung tissues from the TCGA database. (E) Survival analysis of RAC1 in LUAD from the TCGA database. (F) Analysis of RAC1 expression by IHC in clinical LUAD samples. Scale bar: 100 μm. (G) Pearson correlation analysis of RAC1 with C1GALT1 expression in clinical LUAD samples. (H) Overall survival analysis of LUAD patients based on RAC1 expression in clinical samples. (I) The effect of C1GALT1 on RAC1 expression in LUAD cells was detected by Western blot. (J) The network between RAC1 and C1GALT1 was predicted by the online GeneMANIA tool. Mock, cells transfected with empty plasmid; OV, cells transfected with C1GALT1 overexpression plasmid; shNC, cells infected with negative control shRNA; shRNA1, cells infected with C1GALT1 shRNA1. Data are expressed as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001.