. 2021 Apr 19;12(7):1207–1221. doi: 10.1039/d1md00035g

Lipophilicity and in vitro binding results of PBR316 to the TSPO, CBR and LABs and HABs.

	K _i (TSPO)^a nM	K _i (CBR)^a nM	K _i (LABs)^a nM	K _i (HABs)^a nM	LABs:HABs	Log P_7.5^a
PBR316	6.0 ± 1.4 ([³H]PK11195)	>5000 ([³H]flumazenil)	35.1 ± 5.0	23.1 ± 2.7	1.5	2.16 ± 0.07
PBR316	4.7 ± 1.2 ([³H]Ro 5-4864)	>5000 ([³H]flumazenil)	35.1 ± 5.0	23.1 ± 2.7	1.5	2.16 ± 0.07

n = 3 and p < 0.05.