Table 1:
Patient Demographics. Age and survival are reported as median (range).
| All Patients (171) | No Brain Metastasis (146) | Brain Metastasis (25) | p Value | Symptomatic Brain Metastasis (6) | Asymptomatic Brain Metastasis (19) | p Value | |
|---|---|---|---|---|---|---|---|
| Sex | |||||||
| Male | 81 | 71 | 10 | 0.52 | 2 | 8 | >0.99 |
| Female | 90 | 75 | 15 | 4 | 11 | ||
| Age at Diagnosis (years) | 48.1 (26.4–70.1) | 47.8 (26.4–70.1) | 50.1 (35.0–62.6) | 0.18 | 54.4 (42.8–62.6) | 50.0 (35.0–58.2) | 0.18 |
| Primary | |||||||
| Colon | 125 | 107 | 18 | >0.99 | 4 | 14 | >0.99 |
| Rectal | 46 | 39 | 7 | 2 | 5 | ||
| Stage at Diagnosis | |||||||
| 1 | 3 | 3 | 0 | 0.72 | 0 | 0 | 0.06 |
| 2 | 15 | 13 | 2 | 1 | 1 | ||
| 3 | 41 | 32 | 9 | 4 | 5 | ||
| 4 | 97 | 85 | 12 | 1 | 11 | ||
| Unknown | 15 | 13 | 2 | 0 | 2 | ||
| Synchronous Metastatic Disease | 104 | 89 | 15 | >0.99 | 1 | 14 | 0.02 |
| Metachronous Metastatic Disease | 67 | 57 | 10 | 5 | 5 | ||
| Time from Diagnosis to Metastatic Diagnosis (months) | 0.5 (0–98.9) | 0.5 (0–98.9) | 1.5 (0.5–25.8) | 0.45 | 11.6 (0.5–25.3) | 0.5 (0.5–18.7) | 0.05 |
| Time from Diagnosis to Diagnosis of Brain Met (months) | - | - | 42.8 (9.5–119.2) | - | 53.7 (23.9–97.2) | 41.3 (9.5–119.2) | 0.51 |
| Time from Diagnosis of Metastatic Disease to Diagnosis of Brain Met (months) | - | - | 40.3 (9.1–118.7) | - | 43.7 (12.3–71.4) | 37.4 (9.1–118.7) | 0.74 |
| Survival (months) | |||||||
| From initial diagnosis | 52.5 (8.6–219.6) | 51.6 (8.6–219.6) | 57.0 (13.5–130.8) | 0.51 | 60.2 (28.1–111.4) | 57.0 (13.5–130.8) | 0.91 |
| From detection of brain metastasis | - | - | - | - | 5.8 (2.3–15.5) | 3.3 (0.07–32.3) | 0.78 |