Table 1. . Guanylyl cyclase C-targeted immunotherapeutics in clinical trial.
| Type of immunotherapy | Drug name | Phase | Cancer indication | Status | Identifier |
|---|---|---|---|---|---|
| Vaccine | Ad5-GUCY2C-PADRE | I | Colorectal | Completed | NCT01972737 |
| Ad5.F35-GUCY2C-PADRE | IIa | Gastrointestinal malignancies | Initiated | NCT04111172 | |
| Antibody–drug conjugate | TAK-264 | I | Gastrointestinal malignancies | Completed | NCT01577758 |
| II | Pancreatic | Terminated | NCT02202785 | ||
| Bispecific T-cell engager | PF-07062119 | I | Gastrointestinal malignancies | Ongoing | NCT04171141 |