Table 2.

Common Terminology Criteria for Adverse Events version 5.0 for pneumonitis [61,62,63].

Grade	Incidence	Clinical	Radiologic
1	20–24%	Asymptomatic to minimally symptomatic	ground glass opacities, less than 25% of lung involvement
2	18–22%	symptomatic requiring treatment, limitation of ADLs, but no oxygen requirement	extensive ground glass opacities extending beyond therapy field with signs of no to minimal focal consolidation, involvement of 25 to 50% of lung
3	8–16%	symptoms with oxygen requirement	clear evidence of focal consolidation with or without evidence of fibrosis, more than 50% involvement
4	2–4%	severe symptoms with persistent oxygen requirement or assisted ventilation	dense consolidations, atelectasis, traction bronchiectasis with significant pulmonary volume loss