Table 1.
Subject characteristics stratified by chronic obstructive pulmonary disease status.
| Characteristic | Non-COPDa (n=23,326) | COPD (n=1489) | P value | |
| Age (years), mean (SD) | 42 (9.1) | 48 (9.3) | <.001 | |
| Female, n (%) | 3841 (16.5%) | 58 (3.9%) | <.001 | |
| Smoking status, n (%) |
|
|
<.001 | |
|
|
Current smoker | 10,632 (45.6%) | 1,021 (68.6%) |
|
|
|
Exsmoker | 3534 (15.2%) | 202 (13.6%) |
|
|
|
Nonsmoker | 9153 (39.3%) | 266 (17.9%) |
|
|
|
Unknown/missing | 7 (0.0%) | 0 (0.0%) |
|
| BMI (kg/m2), mean (SD) | 23 (3.2) | 22 (2.7) | <.001 | |
| Lung function test, mean (SD) |
|
|
|
|
|
|
Prebronchodilator FEV1b | 3.4 (0.7) | 3.1 (0.6) | <.001 |
|
|
Prebronchodilator FVCc | 4.1 (0.8) | 4.2 (0.8) | <.001 |
|
|
Prebronchodilator FEV1/FVC | 83.7 (5.4) | 74.9 (5.1) | <.001 |
| Comorbidity, n (%) |
|
|
|
|
|
|
Arrythmia | 107 (0.5%) | 16 (1.1%) | .003 |
|
|
Duodenal ulcer | 158 (0.7%) | 19 (1.3%) | .02 |
|
|
Colorectal polyp | 43 (0.2%) | 13 (0.9%) | <.001 |
|
|
Angina | 56 (0.2%) | 10 (0.7%) | .006 |
|
|
Stomach ulcer | 180 (0.8%) | 29 (1.9%) | <.001 |
|
|
Kidney disease | 77 (0.3%) | 12 (0.8%) | .01 |
| Computed tomography finding, n (%) |
|
|
|
|
|
|
Bulla, bleb | 108 (0.5%) | 31 (2.1%) | <.001 |
|
|
Moderate emphysema | 18 (0.1%) | 13 (0.9%) | <.001 |
|
|
Mild emphysema | 96 (0.4%) | 27 (1.8%) | <.001 |
|
|
Calcification of left anterior descending coronary artery | 128 (0.5%) | 16 (1.1%) | .02 |
|
|
Chronic inflammation | 342 (1.5%) | 43 (2.9%) | <.001 |
| Laboratory parameters, mean (SD) |
|
|
|
|
|
|
Albumin (U/L) | 4.4 (0.2) | 4.3 (0.2) | <.001 |
|
|
Alanine aminotransferase (U/L) | 209.5 (53.7) | 215.2 (54.6) | <.001 |
|
|
Aspartate aminotransferase (U/L) | 26.4 (14.8) | 24.3 (12.8) | <.001 |
|
|
Blood urea nitrogen (mg/dL) | 14.1 (3.2) | 14.7 (3.3) | <.001 |
|
|
Cholinesterase (U/L) | 320.8 (60.1) | 307.8 (58.8) | <.001 |
|
|
Estimated glomerular filtration rate (mL/min/1.73 m2) | 83.6 (14.6) | 80.2 (14.1) | <.001 |
|
|
Eosinophil count (cells/mm3) | 183.2 (124.5) | 195.4 (125.9) | <.001 |
|
|
Gamma-glutamyl transferase (U/L) | 42.7 (34.4) | 45.8 (34.5) | <.001 |
|
|
Hemoglobin (g/dL) | 14.7 (1.4) | 14.9 (1.1) | <.001 |
|
|
Hemoglobin A1c (%) | 5.3 (0.7) | 5.4 (0.7) | <.001 |
|
|
Hematocrit (%) | 44.0 (3.6) | 44.6 (3.1) | <.001 |
|
|
MCHd (pg) | 30.5 (1.8) | 31.1 (1.7) | <.001 |
|
|
MCHCe (g/L) | 33.4 (1.0) | 33.3 (0.8) | <.001 |
|
|
MCVf (fL) | 91.3 (4.6) | 93.4 (4.4) | <.001 |
|
|
WBCg count (×102 cells/µL) | 58.8 (15.0) | 62.8 (15.5) | <.001 |
aCOPD: chronic obstructive pulmonary disease.
bFEV1: forced expiratory volume in 1 second.
cFVC: forced vital capacity.
dMCH: mean corpuscular hemoglobin.
eMCHC: mean corpuscular hemoglobin concentration.
fMCV: mean corpuscular volume.
gWBC: white blood cell.