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. 2021 Jun 10;10(2):23. doi: 10.3390/antib10020023

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Modifications of a di-proline motif in the CDR H3 alter the SEC profile. (A) Prolines at residues 100f and 100g are highlighted in stick representation (Kabat residue numbering is used for antibody). (B) The SEC profile of 10E8v4. (C) The SEC profile of 10E8v4-P100fa. (D) The SEC profile of 10E8v4-P100gA. (E) The SEC profile of 10E8v4-P100fA+P100gA. (F) The SEC profile of VRC01.