Table 1.
Different delivery system for the different type of mRNA vaccine.
| Sl. no | miRNA vaccine type | Route of entry | Disease | Reference | |
|---|---|---|---|---|---|
| 1. | Vector based mRNA | Lipid nanoparticles | Intravenous | Anaemia | (37) |
| 2. | Melanoma | (38) | |||
| 3. | Subcutaneous | AIDS | (39) | ||
| 4. | Nasal pumping | Cystic fibrosis | (40) | ||
| 5. | Intramuscular | Respiratory syncytial virus infection | (41) | ||
| 6. | ZIKV | (42) | |||
| 7. | H10N8 and H7N9 | (43, 44) | |||
| 8. | Polymer-based | Subretinal injections | Retina diseases | (45) | |
| 9. | Intravenous | Pulmonary vascular disease | (46) | ||
| 10. | Anaemia, myelodysplasia | (47) | |||
| 11. | Subcutaneous | AIDS | (48) | ||
| 12. | Muscle atrophy | (49) | |||
| 13. | Lipid and polymer hybrid | Intravenous | Ornithine transcarbamylase deficiency | (50) | |
| 14. | Lymphoma | (51) | |||
| 15. | Protamine-formulated | Intradermal | Melanoma | (52) | |
| 16. | Prostate cancer | (53) | |||
| 17. | Non-small cell lung cancer | (54, 55) | |||
| 18. | Intradermal, intramuscular | Rabies | (56) | ||
| 19. | Infectious diseases, cancer | (57, 58) | |||
| 20. | Intradermal | Ovarian cancer | (59) | ||
| 21. | Ex vivo loading of dendritic cells | Subcutaneous | Different tumors | (60) | |
| 22. | Intradermal | Acute myeloid leukaemia | (61) | ||
| 23. | Naked mRNA | Subcutaneous tumors, intranodal | Cervical cancer | (62) | |
| 24. | Intradermal | Melanoma | (63) | ||
| 25. | Intranodal | Cancer | (64) | ||
| 26. | Intradermal (Electroporation) | – | (65) | ||
| 27. | Gene gun | Melanoma | (66) | ||
| 28. | Intradermal (Microneedles) | – | (67) | ||