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. 2021 Jul 7;12:679344. doi: 10.3389/fimmu.2021.679344

Table 2.

Different mRNA based cancer vaccines which are registered for different phases of the clinical trial.

Vaccine targets Clinical trials no. Status (Phase) Vaccine type Sponsor/Organization
Prostate cancer NCT01817738 Terminated (I/II) RNActivetumour-associated antigen mRNA CureVac AG
NCT00831467 Completed (I/II)
NCT02140138 Terminated (II)
NCT01446731 Completed (II) Dendritic cell loaded with tumour-associated antigen mRNA Herlev Hospital
NCT01197625 Recruiting (I/II) Oslo University Hospital
NCT01278914 Completed (I/II)
NCT00906243 Terminated (I/II) RNActivetumour-associated antigen mRNA University of Florida
Glioblastoma NCT02649582 Recruiting (I/II) Dendritic cell electroporated with tumour-associated antigen mRNA Antwerp University Hospital
NCT02465268 Recruiting (II) Dendritic cell loaded with cytomegalovirus antigen mRNA with granulocyte–macrophage colony-stimulating factor protein University of Florida
NCT02366728 Active (II) Dendritic cell loaded with cytomegalovirus antigen mRNA Duke University
NCT00626483 Completed (I)
NCT02529072 Completed (I)
NCT00639639 Active (I)
NCT00890032 Completed (I) Dendritic cell loaded with autologous tumour mRNA
NCT02709616 Active (I) Dendritic cell loaded with tumour-associated antigen mRNA Guangdong 999 Brain Hospital
NCT02808364
NCT00846456 Completed(I/II) Dendritic cell loaded with autologous tumour or tumour-associated antigen mRNA Oslo University Hospital
Pancreatic cancer NCT00664482 Completed (Not applicable) Dendritic cell electroporated with autologous tumour mRNA with or without CD40L mRNA Argos Therapeutics
Melanoma NCT02035956 Completed (I) Naked tumour-associated antigen or neo−Ag mRNA BioNTech RNA Pharmaceuticals GmbH
NCT01684241
NCT02410733 Active (I) Liposome-complexed tumour-associated antigen mRNA
NCT01216436 Terminated Dendritic cell, matured, loaded with tumour-associated antigen mRNA Duke University
NCT01456104 Active (I) Dendritic cell (Langerhans) electroporated with tumour-associated antigen mRNA Memorial Sloan Kettering Cancer Center
NCT01278940 Completed (I/II) Dendritic cell loaded with autologous tumour or tumour-associated antigen mRNA Oslo University Hospital
NCT00961844 Terminated (I/II)
NCT02285413 Completed (II) Dendritic cellelectroporated with tumour or tumour-associated antigen mRNA Radboud University
NCT01530698 Completed (I/II)
NCT00940004 Completed (I/II)
NCT00243529 Completed (I/II)
NCT00929019 Terminated (I/II)
Melanoma NCT00204516 Completed (I/II) Autologous tumour mRNA with granulocyte–macrophage colony-stimulating factor protein University Hospital Tübingen
NCT00204607 Completed (I/II) Protamine-complexed tumour-associated antigen mRNA with macrophage colony-stimulating factor protein
NCT01983748 Recruiting (III) Matured Dendritic cell, loaded with autologous tumour RNA University Hospital Erlangen
NCT01676779 Completed (II) Dendritic cellelectroporated with tumour-associated antigen and TriMix mRNA UniversitairZiekenhuisBrussel
NCT01066390 Completed (I)
NCT01302496 Completed (II)
Colorectal cancer NCT00228189 Completed (I/II) Dendritic cellelectroporated with tumour-associated antigen mRNA Radboud University
Ovarian cancer NCT01334047 Terminated (I/II) Dendritic cell loaded with autologous tumour or tumour-associated antigen mRNA Oslo University Hospital
NCT01456065 Unknown Matured Dendritic cell, loaded with autologous tumour RNA Life Research Technologies GmbH
Breast cancer z NCT02316457 Active (I) Liposome-formulated tumour-associated antigen and neo−antigen mRNA BioNTech RNA Pharmaceuticals GmbH
NCT00978913 Completed (I) Dendritic cellloaded with tumour-associated antigen mRNA Herlev Hospital
Acute Myeloid Leukemia NCT00514189 Terminated (I) Dendritic cell loaded with Acute Myeloid Leukemia lysate and mRNA MD Anderson Cancer Center
NCT01734304 Completed (I/II) Dendritic cell loaded with tumour-associated antigen and cytomegalovirus antigenmRNA Ludwig-Maximilian-University of Munich
NCT00510133 Completed (II) Dendritic cell loaded with tumour-associated antigen mRNA AsteriasBiotherapeutics
NCT00965224 Unknown (II) Dendritic cellelectroporated with tumour-associated antigen mRNA Antwerp University Hospital
NCT01686334 Recruiting (II)
NCT00834002 Completed (I)
NCT03083054 Active (I/II) Dendritic cell loaded with tumour-associated antigen mRNA University of Campinas, Brazil
Brain metastases NCT02808416 Active (I) Dendritic cell loaded with tumour-associated antigen mRNA Guangdong 999 Brain Hospital
Non-small-cell lung cancer NCT01915524 Terminated (I) RNActivetumour-associated antigen mRNA CureVac AG
NCT00923312 Completed (I/II)
Renal cell carcinoma NCT00087984 Completed (I/II) Dendritic cell electroporated with autologous tumour mRNA with or without CD40L mRNA Argos Therapeutics
NCT01482949 Terminated (II)
NCT01582672 Terminated (III)
NCT00678119 Completed (II)
NCT00272649 Completed (I/II)
Mesothelioma NCT02649829 Recruiting (I/II) Dendritic cell electroporated with tumour-associated antigen mRNA Antwerp University Hospital