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. 2021 Jul 2;6(3):121. doi: 10.3390/tropicalmed6030121

Figure 7.

Figure 7

CD4 lethal cytokine signature. (A) Intrastrain comparisons revealed significant increase in IFN-IL2 production in the lethal model at 10 dpi compared to the nonlethal models at 14 and 21 dpi; significant increases in IL2-TNF-IFN production were observed in the lethal model at 10 and 14 dpi compared to the nonlethal model at 21 dpi. (B,C) In both interstrain comparisons, significant increases in IFN-IL2 and IL2-TNF-IFN were observed in the lethal model at 10 and 14 dpi when compared to nonlethal models at both 10 and 21 dpi. Significant differences between average cytokine populations in the lethal and nonlethal models are indicated by asterisks (*, p < 0.05).