Table 3.
Costs and Effectiveness of Interventions on the Cost-Effectiveness Frontier.
| Intervention Timing | Doxycycline Treatment Expanded Coverage | Doxycycline Prophylaxis Distribution Rate, People/Day (Final Coverage as % of Total Population) | Malathion Distribution Coverage | Total Cost | Total QALYs | Incremental Cost | Incremental QALYs | ICER (Cost/QALY Gained) |
|---|---|---|---|---|---|---|---|---|
| N/A | 0% | 0 (0%) | 0% | $0 | 0 | N/A | N/A | N/A |
| Day 10 | 10% | 0 (0%) | 0% | $13,620 | 57.7 | $13,620 | 57.7 | $236 |
| Day 10 | 20% | 0 (0%) | 0% | $29,290 | 113.9 | $15,670 | 56.2 | $279 |
| Day 10 | 30% | 0 (0%) | 0% | $47,000 | 168.4 | $17,710 | 54.5 | $325 |
| Day 10 | 40% | 0 (0%) | 0% | $66,750 | 221.5 | $19,750 | 53.1 | $372 |
| Day 10 | 50% | 0 (0%) | 0% | $88,550 | 273.1 | $21,800 | 51.6 | $422 |
| Day 10 | 60% | 0 (0%) | 0% | $112,400 | 323.3 | $23,840 | 50.2 | $475 |
| Day 10 | 70% | 0 (0%) | 0% | $138,300 | 372.1 | $25,880 | 48.8 | $530 |
| Day 10 | 80% | 0 (0%) | 0% | $166,200 | 419.7 | $27,920 | 47.6 | $587 |
| Day 10 | 90% | 0 (0%) | 0% | $195,000 | 465.9 | $28,850 | 46.2 | $624 |
| Day 10 | 100% | 0 (0%) | 0% | $227,000 | 511.0 | $31,950 | 45.1 | $709 |
| Day 1 | 100% | 0 (0%) | 0% | $259,400 | 542.7 | $32,380 | 31.7 | $1023 |
| Day 1 | 100% | 1000 (%) | 0% | $879,600 | 934.9 | $620,200 | 392.2 | $1581 |
| Day 1 | 100% | 2000 (%) | 0% | $1,567,000 | 1252 | $687,600 | 317.1 | $2169 |
| Day 1 | 100% | 3000 (%) | 0% | $2,318,000 | 1509 | $751,100 | 257.5 | $2917 |
| Day 1 | 100% | 4000 (%) | 0% | $3,129,000 | 1720 | $811,000 | 210.3 | $3857 |
| Day 1 | 100% | 5000 (%) | 0% | $3,997,000 | 1892 | $867,400 | 172.6 | $5027 |
| Day 1 | 100% | 6000 (%) | 0% | $4,917,000 | 2035 | $920,600 | 142.4 | $6465 |
| Day 1 | 100% | 6000 (%) | 10% | $5,529,000 | 2115 | $612,100 | 80.7 | $7584 |
| Day 1 | 100% | 7000 (%) | 10% | $6,500,000 | 2228 | $970,800 | 112.1 | $8658 |
| Day 1 | 100% | 7000 (%) | 20% | $7,201,000 | 2295 | $701,200 | 68.0 | $10,310 |
| Day 1 | 100% | 8000 (%) | 20% | $8,220,000 | 2384 | $1,018,00 | 88.7 | $11,470 |
| Day 1 | 100% | 8000 (%) | 30% | $9,010,000 | 2442 | $790,300 | 57.3 | $13,790 |
| Day 1 | 100% | 9000 (%) | 30% | $10,070,000 | 2512 | $1,063,000 | 70.6 | $15,060 |
| Day 1 | 100% | 9000 (%) | 40% | $10,950,000 | 2560 | $879,200 | 48.3 | $18,200 |
| Day 1 | 100% | 10,000 (%) | 40% | $12,060,000 | 2617 | $1,105,000 | 56.4 | $19,570 |
| Day 1 | 100% | 10,000 (%) | 50% | $13,020,000 | 2658 | $968,200 | 40.8 | $23,760 |
| Day 1 | 100% | 10,000 (%) | 60% | $14,080,000 | 2694 | $1,057,000 | 36.5 | $28,930 |
| Day 1 | 100% | 10,000 (%) | 70% | $15,230,000 | 2727 | $1,146,000 | 32.7 | $35,000 |
| Day 1 | 100% | 10,000 (%) | 80% | $16,460,000 | 2756 | $1,234,000 | 29.4 | $42,050 |
| Day 1 | 100% | 10,000 (%) | 90% | $17,780,000 | 2783 | $1,323,000 | 26.4 | $50,200 |
| Day 1 | 100% | 10,000 (%) | 100% | $19,200,000 | 2806 | $1,412,000 | 23.7 | $59,540 |
ICER = incremental cost-effectiveness ratio, QALY = quality-adjusted life year.