Table 1.
Overview of the study population and alpha diversity analysis results with Shannon diversity index and observed richness. NCL—non-contact-lens users. CL—contact lens users. CLABK_fellow = eye without contact-lens-associated bacterial keratitis; CLABK = eye with contact-lens-associated bacterial keratitis: IQR—Interquartile range; ASV—amplicon sequence variant.
| NCL | CL | CLABK_fellow and CLABK | p-Values | |
|---|---|---|---|---|
| Number of participants | 28 | 26 | 9 | - |
| Age (years) median (IQR) | 32 (28–35) | 33 (26–38) | 44 (32–52) | 2.2 × 10−16 1 |
| Sex (%) (F/M) | 50%/50% | 61%/39% | 56%/44% | - |
| Number of samples | 56 (left and right eye) |
52 (left and right eye) |
18 (n = 9 eye CLABK_fellow and n = 9 eye CLABK) |
- |
| Number of positive cultures from corneal swabs | NA | NA | 5 (56%) | - |
|
Shannon diversity index
Median (IQR) * |
4.6 (4.3–5.0) |
4.5 (4.1–5.0) |
CLABK_fellow 3.9 (3.8–4.5) CLABK 4.8 (3.6–5.2) |
0.48 2 0.48 3 |
|
Observed richness for ASV level
Median (IQR) * |
297 (247–335) |
281 (220–337) |
CLABK_fellow 251 (174–281) CLABK 314 (206–359) |
0.56 2 0.40 3 |
|
Observed richness for genus level
Median (IQR) * |
30 (24–33) |
25 (23–30) |
CLABK_fellow 27 (19–29) CLABK 28 (19–34) |
0.52 2 0.45 3 |
* For the NCL and CL groups, one randomized eye was included to calculate the Shannon diversity index and observed richness. 1 Kruskal–Wallis test. 2 Comparison of NCL vs. CL vs. CLABK_fellow with the Kruskal–Wallis test. 3 Comparison of NCL vs. CL vs. CLABK with the Kruskal–Wallis test.