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. 2021 Jun 22;11(3):94–114. doi: 10.3390/jox11030007

Table 2.

Genetic variability and importance of the main CYP isoenzymes involved the metabolism of xenobiotics.

CYCYP Isoenzyme Polymorphism Frequency Functional Effects Allelic Variants Participation in the Metabolism of Xenobiotics
1A1 Relatively high Rare 13 graphic file with name jox-11-00007-i001.jpg
1A2 High Rare 21
1B1 Frequent missense mutations Rare 26
2A6 Higher in Orientals than in Caucasians Significant 45
2B6 High Significant 38
2C8 High Significant 14
2C9 Relatively rare in Caucasians Very significant 70
2C19 High Very significant 38
2D6 Very High Highly significant 145
2E1 Low No significance 7
3A4 Low Low significance 32
3A5 High Significant 9
Other (a) - - -

(a) Other CYP isoenzymes involved in smaller fraction of xenobiotic metabolism (2A13, 2C18, 2F1, 2J2, 3A7 and some members of the CYP4 family). Due to substrate overlapping specificity, CYP1B1 (typical sterols metabolizer) and 2J2 (typical fatty acids metabolizer) were also included in the CYP xenobiotic metabolizer analysis.