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. 2021 Jul 7;12:720734. doi: 10.3389/fendo.2021.720734

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Copyright © 2021 Dao and François

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The endocannabinoid system within the kidney (A) Distribution of main endogenous ligands and cannabinoid receptors in healthy kidneys. (B) Biosynthesis and degradation of anandamide. The pathways that were demonstrated within the kidney are in blue. The other pathways are in black. (C) Biosynthesis and degradation of 2-arachidonoyl-glycerol. The pathways that were demonstrated within the kidney are in blue. The other pathways are in black. 2AG, 2-arachidonoyl-glycerol; ABHD, α/β-Hydrolase domain containing; AEA, anandamide; CB1R, cannabinoid receptor type 1; CB2R, cannabinoid receptor type 2; COX2, cyclooxygenase 2; CYP, cytochrome P450; DAG, diacylglycerol; DAGL, sn-1-specific diacylglycerol lipase; DDHD1, phosphatidic acid-preferring phospholipase A1; EET-EA, epoxyeicosatrienoic acid-ethanolamine; FAAH, fatty acyl amide hydrolase; HETE-EA, hydroxyeicosatetraenoic acid-ethanolamine; LPA, lysophosphatidic acid; MAGL, monoacylglycerol lipase; NAPE, N-arachidonoyl phosphatidyl ethanolamine; PDE, phosphodiesterase; PIP2, 2-arachidonoyl-phosphatidylinositol 4,5-bisphosphate; PLA2, phospholipase A2; PLC, phospholipase C; PLD, phospholipase D.