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. 2021 Jun 7;9(2):27. doi: 10.3390/proteomes9020027

Figure 4.

Figure 4

RyR2 S2814 phosphorylation-dependent interaction with Aifm1 and Idh3b. Western blot of RyR2 immunoprecipitated (IP) from lysates of ventricles from wild-type (WT), S2814A (SA), and S2814D mice showing differential RyR2 co-immunoprecipitation (co-IP) with Aifm1 and Idh3b (A). Quantification of co-immunoprecipitated proteins normalized to immunoprecipitated RyR2 (relative to WT) showing significantly reduced RyR2/Aifm1 (B) and RyR2/Idh3b (C) interactions in S2814D mice compared to both WT and S2814A mice. * p < 0.05; ** p < 0.01.