Table 2.

Information on the SNPs showing significant interactions with in utero diabetes exposure in regression models of BMI z-scores in the EPOCH cohort. This table shows the regression results for the interaction terms between the SNPs and intrauterine diabetes exposure statuses from the regression models of the BMI z-score in EPOCH and Project Viva (controlling for birthweight and the first three genetic principal components), as well as the meta-analyzed results for the interaction terms with nominally significant variants shown in bold. The consistency of the observed interaction effect sizes across the two studies was assessed using the I² statistic, which describes the percentage of variation across studies that is due to heterogeneity rather than chance.

						EPOCH				Project Viva				Meta-Analysis
							Interaction				Interaction			Interaction				Heterogeneity
SNP	Effect Allele	Other Allele	Chr.	Position (bp)	Nearest Gene	Effect Frequency	Beta	SE	p	Effect Frequency	Beta	SE	p	Beta	SE	p	FDR	I²	p
rs17203016	G	A	2	207963763	CREB1	0.19	−0.57	0.26	0.028	0.19	0.50	0.38	0.19	−0.23	0.21	0.274	0.27	81.4	0.02
rs2176040	A	G	2	226801046	LOC646736	0.36	−0.52	0.22	0.018	0.34	0.30	0.26	0.25	−0.19	0.17	0.272	0.27	82.7	0.02
rs17001654	G	C	4	77348592	SCARB2	0.15	0.54	0.26	0.035	0.15	0.48	0.45	0.29	0.53	0.22	0.019	0.065	0	0.90
rs10733682	A	G	9	128500735	LMX1B	0.48	0.41	0.21	0.050	0.45	0.36	0.28	0.19	0.39	0.17	0.018	0.065	0	0.90
rs16951275	T	C	15	65864222	MAP2K5	0.77	0.49	0.20	0.016	0.76	0.03	0.33	0.92	0.37	0.17	0.034	0.080	29.7	0.23
rs1558902	A	T	16	52361075	FTO	0.41	0.42	0.21	0.044	0.36	0.12	0.30	0.69	0.32	0.17	0.061	0.086	0	0.40
rs9914578	G	C	17	1951886	SMG6	0.23	−0.54	0.22	0.016	0.27	−0.03	0.26	0.91	−0.33	0.17	0.056	0.086	54.5	0.14