Table 3.
Interactions between the genetic risk scores (GRSs) and intrauterine exposure to maternal diabetes in relation to the BMI z-scores in the EPOCH cohort. This table shows the regression results for the interaction terms between the GRSs and intrauterine diabetes exposure statuses from the regression models of the BMI z-score in the EPOCH cohort (controlling for birthweight and the first three genetic principal components). Weighted and unweighted GRSs were calculated for (i) all 95 BMI-associated SNPs examined in this study and (ii) the subset of eight SNPs showing nominally significant interactions with intrauterine diabetes exposures in EPOCH.
| EPOCH | |||||
|---|---|---|---|---|---|
| Mean (SD) | Interaction | ||||
| Component SNPs | GRS | Beta | Standard Error | p | |
| 95 BMI-associated SNPs | Weighted | 2.25 (0.15) | 0.60 | 0.97 | 0.53 |
| Unweighted | 89.66 (5.88) | −0.002 | 0.03 | 0.93 | |
| 8 SNPs showing interactions with intrauterine exposure to diabetes | Weighted | 0.16 (0.07) | 3.43 | 2.06 | 0.10 |
| Unweighted | 5.02 (1.72) | 0.12 | 0.10 | 0.24 | |