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Exosomes isolated from epileptogenic tissue are enriched with microRNAs having G/U-rich motifs that activate TLR7/8. The sequences of 37 microRNAs increased in the cargo of epileptogenic exosomes were analyzed for nucleic acid motifs that function as ligands and activators of TLR7/8. The frequency of TLR7/8 motifs is significantly higher in the set of 37 exosomal microRNAs compared to the overall set of human microRNAs (p = 0.017, hypergeometric test).
