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. 2021 Jul 16;4(3):49. doi: 10.3390/mps4030049

Figure 1.

Figure 1

Overview of the HiChIP protocol. (a) Outline of the HiChIP protocol. The red star indicates fragments with dangling ends. (b) Comparison of the sequencing read statistics of SATB1 and CTCF HiChIP experiments. The original HiChIP protocol performed in our laboratory yielded a high number of fragments with dangling ends. The improved version of the protocol provided in this work substantially decreased the number of invalid pairs, including the dangling end pairs. Comparison with the publicly available CTCF HiChIP experiment [15] is provided.