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. 2021 Jul 21;54:21. doi: 10.1186/s40659-021-00345-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Interaction pathway of mmu-miR-21, mmu-miR-146b and mmu-miR-155 and target genes. These data reveal the interaction of 54 target genes for mmu-miR-21, 14 target genes for mmu-miR-146b and 28 target genes for mmu-miR-155. Red arrows indicate the genes related to virulence by T. cruzi and host immune response. CAMP Responsive Element Binding Protein 1(Creb1), Mitogen-Activated Protein Kinase Kinase Kinase 1 (Map3k1), IQ Motif Containing GTPase Activating Protein 1(Iqgap1), BCL2 Apoptosis Regulator (Bcl2), SMAD Family Member 5 (Smad5), Nuclear factor of activated T cells 1 (Nfatc1), Glicogen Synthase Kinase 3 beta (Gsk3b), Nuclear factor of activated T cells 5 (Nfat5) and Insulin like grown factor 1 receptor (Igf1r)