Table 1.
Comparison of main clinical features in normal controls and PCOS subjects
| Item | Normal control | PCOS | P-value | |
|---|---|---|---|---|
|
Normal weight (BMI < 25) |
Overweight /Obese (BMI ≥ 25) |
|||
| N | 33 | 33 | 34 | |
| SFRP5 (ng/ml) | 63.98 ± 12.40 | 37.99 ± 10.80c | 32.77 ± 8.31c | < 0.001 |
| Age(years) | 27.97 ± 3.86 | 26.97 ± 2.82 | 29.06 ± 3.86 | 0.293 |
| BMI (Kg/m2) | 20.70 ± 2.14 | 21.62 ± 1.98 | 28.28 ± 2.40c,f | < 0.001 |
| WHR | 0.79 ± 0.03 | 0.79 ± 0.04 | 0.84 ± 0.02c,f | < 0.001 |
| AMH (ng/ml) | 2.86 ± 0.70 | 5.52 ± 2.02c | 6.62 ± 2.83c | < 0.001 |
| FSH (mIU/ml) | 7.58 ± 1.95 | 6.18 ± 1.87a | 6.89 ± 2.21 | 0.036 |
| LH (mIU/ml) | 7.01 ± 1.77 | 12.46 ± 9.99a | 9.42 ± 6.24 | 0.023 |
| FAI | 2.15 ± 0.56 | 5.98 ± 2.47c | 6.92 ± 3.09c | < 0.001 |
| FINS (Uiu/ml) | 5.4(4.3,6.5) | 5.97(4.85, 9.15) | 12.99(10.83,14.85)c,f | < 0.001 |
| 2-h INS (Uiu/ml) | 18.5(13.22,27.87) | 41.2 (33.94,81.95)c | 99.49(67.99,138.86)c,e | < 0.001 |
| FBG (mmol/l) | 4.91 ± 0.23 | 5.31 ± 0.33c | 5.71 ± 0.61c | < 0.001 |
| 2-hBG (mmol/l) | 5.74 ± 1.00 | 7.58 ± 1.92c | 9.01 ± 2.30c | < 0.001 |
| TG (mmol/L) | 1.00 ± 0.23 | 1.17 ± 0.58 | 2.27 ± 0.91c,f | < 0.001 |
| TC (mmol/L) | 4.36 ± 0.44 | 4.49 ± 0.51 | 4.78 ± 0.53b | 0.007 |
| HDL-C (mmol/L) | 1.41 ± 0.31 | 1.28 ± 0.27 | 1.24 ± 0.22 | 0.022 |
| LDL-C (mmol/L) | 2.55 ± 0.40 | 2.55 ± 0.34 | 2.91 ± 0.41b,e | 0.056 |
| HbA1c(%) | 5.35 ± 0.24 | 5.60 ± 0.28b | 5.77 ± 0.28c | < 0.001 |
| AUCI | 75.66(66.10,88.95) | 148.82(106.4,255.49)c | 265.94(195.23,388.22)c,e | < 0.001 |
| AUCG | 18.70 ± 2.40 | 25.21 ± 4.87c | 27.78 ± 4.69c | < 0.001 |
| HOMA-IR | 1.17(0.97,1.44) | 1.54(1.01, 2.05) | 3.28(2.56, 4.06)c,f | < 0.001 |
| IL6(pg/ml) | 4.48 ± 2.94 | 47.65 ± 30.68c | 52.30 ± 39.06c | < 0.001 |
| TNFα (ng/ml) | 16.08 ± 3.17 | 61.36 ± 13.68c | 61.27 ± 10.95c | < 0.001 |
Values are presented as mean ± standard deviation (SD) or medians (25th, 75th percentiles)
WHR waist-to-hip ratio, AMH anti-Müllerian hormone, FAI the free androgen index, FBG fasting blood glucose, 2-hBG 2-h blood glucose, FINS fasting insulin, 2-h Ins 2-h plasma insulin after glucose overload, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, AUCI the area under the curve of insulin, AUCG the area under the curve of glucose, HOMA-IR the homeostasis model assessment of IR
P value: total PCOS compared to the control
a,b and c p < 0.05, p < 0.01 and p < 0.001 as compared to the control
d, e and f p < 0.05, p < 0.01 and p < 0.001 as compared to normal weight PCOS (BMI < 25)