Fig. 2.

Schematic panel evidencing the complexity of dedifferentiation status and inflammatory microenvironment of thyroid cancer. As demonstrated by Wang et al., thyroid carcinoma cells can exhibit high-risk dedifferentiation behavior, which enhances the epithelial to mesenchymal transition, TNFα signaling, and some common immune system-related signaling pathways, including the pathway IL-6 / JAK / STAT3, interferon alpha and gamma response. Furthermore, the dedifferentiation status appears to be accompanied by an immunological profile characteristic of the immune microenvironment of the tumor, suggesting that the two are closely related