Fig. 1.

Data modelling methodology. Data modelling was performed in three main steps. The estimated resources needed in HD centres to perform the IT administration of an HD DMT per year was calculated, while accounting for the number of patients who are anticipated to need treatment in the future. The resources currently available in HD centres for the procedure were then estimated. Calculations from Steps 1 and 2 were used to quantify the current estimated capacity gap in HD centres for the IT administration procedure. DMT, disease-modifying therapy; HCP, healthcare professional; HD, Huntington’s disease; IT, intrathecal; TAEs, therapy area experts.